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From
the times immemorial, human being is using herbs (other
than those such as foods, vegetables and fruits) for
protecting health or treating diseases. Much before
the evolution of Ayurveda, Indians used the herbs
for their therapeutic values. Centuries of research
work could enlighten the medical researchers towards
devising, various processing methodologies and convert
them into convenient dosage forms.
From the study of the available literature it appears
that the scientific work on formulating therapeutic
dosage forms from herbs must have started somewhere
around the time of Charak Samhita (Approx. 1500 BC).
Similarly the endeavours to design the herbo-mineral/metallic
formulations (Rasoushadhis) must have started somewhere
around 1000 BC as an innovative concept of providing
maximum benefits in minimum possible dosage. Pharmaceutical
procedures, as simple as preparing an infusion or
decoction and as complicated as converting a liquid
metal into a solidified form or manufacturing herbo-metallic
compounds by sublimation, distillation processes were
all developed by the creative scientists upto 16th
century AD. The list of classical Ayurvedic formulations
comprises of more than 10,000 products and includes
remedial measures for the diseases of almost all the
systems.
The indefatigable efforts of medical and para-medical
researchers have undoubtedly revolutionised the process
of evolution in designing newer dosage forms in last
50 years or so, complemented by the scientific advances
in the field physics, chemistry, engineering and bio-technology.
In Ayurvrda phamacognosy has great importance. The
ancient books recommend, the type of plants to be
used & the locations from where these should be procured.
Ayurveda also states the parts of plants that should
be used and its methodology. In modern times also
it is recognized that no two similar plants from two
different locations can have same phytochemistry.
Korean red ginseng is the fine example of the routinely
used medicinal plant in the modern medicine. Selection
of right herb is therefore very important while formulating
an Ayurvedic medicine.
Ayurveda has also prescribed the method of manufacturing.
Ayurveda prescribes methods for purification of various
herbs. This practice is followed to eliminate the
ill effects of unwanted components from the herbs.
Just a physical washing with water does not purify
the plant or the herbs; it may just clean it from
the dust and the dirt attached to it. The plant or
the herb needs to be treated in a particular fashion
to devoid it from the undesired components. Only when
the manufacturer follows these specific methods, one
can expect right kind of formulation.
Various methods of extractions have been well documented
in the ancient literature. Generally the extracts
used in Ayurvedic medicines are aqueous extracts.
The modern methods of extractions can be based on
extractions with the help of alcohol. Many of he formulations
in Ayurveda are based upon extracts; therefore method
of extraction assumes greater importance in Ayurvedic
formulations.
Usually
Ayurvedic formulations have multiple ingredients.
These are generally essential, because, in Ayurveda,
all the ingredients provided in the formulations have
specific actions and in the combinations its not just
one or two active ingredients, but the formulation
in totality is considered active. Some of the ingredients
in the formulation need special treatment, Bhavana,
and this again is a special technique, that makes
the formulation effective.
The instrumentation and modern pharmaceutics has contributed
for advancement of the Ayurvedic medicines. Standardization
of the extracts has been possible due to the modern
technology. Markers have been developed and the chromatographs
have become an important tool for the manufacturer
to provide consistency in the formulations, batch
after batch. Modern QC techniques are of great help
to ensure QA.
The
principles of pharmaceutics help in developing better
product. Be it a tablet or a capsule or a liquid oral
formulation. Friability, disintegration time have
a role to play when the shift from age-old method
of manufacturing to the modern method takes place.
Oral liquids become more palatable to ensure the patient
compliance. Local applications are more acceptable
and are of aesthetic value. The packaging has not
only added the cosmetic elegance, but has also enhanced
the product life and quality.
Unfortunately
there is no specific treatment in the modern medicine
for the cure of certain disease conditions. For example
there is no formulation that can cure Jaundice in
the modern medicine, however Ayurveda has specific
formulations that can treat this dreaded condition.
Ayurveda has formulations that can take care of diabetes.
Cardioprotectives from Ayurveda are well documented.
Ayurveda has well established and accepted rejunavators,
vitalisers and anti ageing drugs just to name the
few. Ayurveda thus in this modern times is a new hope
for the better quality of life, in this mad world.
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